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Want to know about the latest research findings and hottest jobs in the Pharmaceutical and Biotechnology Industry? Then you’ve come to the right place. When you want up-to-the-minute information and job listings for Clinical Research Associates, Contract Clinical Research Associates and Clinical Trial Managers, Sterling-Hoffman Life Sciences Journal is the source to turn to. |
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"While you are experimenting, do not remain
content with the surface of things. Don't become
a mere recorder of facts, but try to penetrate
the mystery of their origin."
- Ivan Petrovich Pavlov (Nobel Prize Laureate in Physiology and Medicine) |
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Optimizing Tissue Micro Array, Technique and Troubleshooting |
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By
Yahya I. Elshimali, MD, Assistant Professor of Pathology and
Laboratory, Medicine, David Geffen School of Medicine, UCLA
Medical Center. LA, California, and Rana M. Issa, MD, Attending
Pathologist, Department of Pathology, Hamburg University,
Germany |
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Tissue Micro Array (TMA) is a high throughput analysis of
paraffin-embedded tissue specimen used for gene validation by
performing immunostaining and fluorescence in situ hybridization
(FISH). It was described first by Kononen et al. and published
in Nature Medicine in 1998(1). Multiple studies were published
about building, validation and using TMA(1,2,3) and TMA became
a very important tool to research laboratories and clinical
applications in centers with a large volume of molecular
testing. |
Read full article
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